June 23, 2019

Sinclair Method: Naltrexone For Alcohol Addiction

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The Sinclair Method

I do not endorse or recommend the Sinclair Method for problem drinkers! I think it’s important that I mention that at the very start of the blog post.

Fans of the Sinclair Method get very upset at even the whiff of such a put-down but I will explain why later in the post.

For me, the concept of taking a drug to fix a drug problem does not make any sense. I tried Naltrexone and it was just another failed attempt at quitting alcohol. The Stop Drinking Expert course and live seminars are the cumulations of what eventually did work.

It has since gone on to help over 100,000 problem drinkers to escape the loop.

Right now let’s explore what the Sinclair Method is and how it is used to treat alcoholism.

What is the Sinclair Method:

The Sinclair Method entails taking a basic tablet, like the prescribed medicine naltrexone (trademark name: Revia), about sixty minutes before you drink alcohol. Gradually, this medicine decreases the urge to consume alcohol. The tablet has no other noticeable impact without drinking and it is non-addictive.

Although some report that the side effects are quite unpleasant and difficult to deal with.

the sinclair method
Dr. David Sinclair

How the ‘Method’ Began

Dr. Sinclair is famous for work with Naltrexone as an anti-alcohol med in The U.S.A. He developed what he named the “alcohol deprival consequence” as a tool to help people deal with severe alcoholism. He eventually relocated to Helsinki, Finland. Where he used specially bred medical rodents genetically disposed to alcohol to test his theories.

The Result of The Sinclair Method Studies?

What he concluded was that alcohol addiction is a mastered behavior or if you prefer, a learned addiction.

To get addicted to alcohol you have to ignore some pretty big warning signs, for quite a long time.

Repetition is the mother of all learning. When you ignore those warning signs for long enough you enter the realms of mastery. Many individuals (and rodents too, would you believe?) have hereditary characteristics. These DNA level pieces of code lead them to experience a great deal of “reinforcement” from drinking alcohol.

The genetic coding makes these people experience a much stronger ‘high’ from the drug. When compared to social drinkers who can ‘take or leave it’.

Ivan Pavlov
Ivan Pavlov

Pavlovian conditioning

The whole theory behind the Sinclar Method is based on the work of Ivan Pavlov. Pavlov is the scientist famous for making dogs drool at the command of a bell.

When trained, dogs treated to a  food-based reward after an alarm had been sounded would drool at the sound of the alarm on its own. However, the less well-known aspect of the experiments was this: Gradually, Pavlov would sound the alarm, but stopped feeding the dogs. Eventually, the dogs stopped responding to the audible anchor.

This is called “elimination theory” and Sinclair believed the mastered habits of a dependency to drinking might be eliminated by elimination, as well.

This is where the drug Naltrexone comes in.

Drinking is a learned addiction

Following his initial study, Sinclair speculated that drinking generates reinforcement in the mind in a manner that resembles narcotics.

His study suggested that drinking created reinforcement of addiction by discharging endorphins. These brain chemicals tie-up with opioid receptors in the human brain. So to activate his elimination theory he just had to find a way to stop the receptors from activating.

lab rats alcohol testing
Testing on lab rats

Success with lab rats

Sinclair used rodents in his tests, making use of a new drug called Naltrexone. Naltrexone is not designed for alcohol use disorders but is instead a narcotic blocker. It is designed to help people addicted to opioids, but it was found to work with alcohol as well.

He started with lab rats and then moved onto human test subjects.

The ‘elimination theory’ offer by Sinclair appropriately implies you need to drink yourself clean!

The premise is you drink but because of the drug, you don’t experience any reward.

This would certainly be the ideal remedy for numerous problem drinkers.  However, as the saying goes ‘if it sounds too good to be true’ etc. Fans of the Sinclair Method will state that is has a 78% success rate. How long that sobriety lasts is another matter entirely.

You have to remember to take the pill

It’s essential to keep in mind that you take the tablet an hour prior to alcohol consumption, not just when you feel like it. Gradually, the need to drink alcohol will decrease and folks wind up refraining the majority of the time or periodically have an alcoholic beverage when they want.

You have to carry on taking the medicine prior to drinking alcohol, even when you feel factors are in control.

There are a handful of individuals who do not appear to react to the medicine, and some people might have an excessive liver injury to make use of this therapy.

The problem with taking any drug is it is going to do harm somewhere in your body.

medication for alcoholism

Not a quick fix

The Sinclair Method is not a silver bullet and may take several months to have the intended impact. For some, it will be a total failure, but that is true of any approach.

Some claim that this might be the future of alcohol addiction therapy. It is popular in the United States to call alcohol addiction a “disease” and this appears to be dealing with it as one.

It will take some time for individuals to acknowledge this kind of a revolutionary principle. As it does violate the total sobriety strategy that the majority of therapy facilities recommend people to use.

The Problem With The Sinclair Method

There is no doubt this method has saved countless lives. The people who love it, REALLY love it!

However, there are several major problems with Naltrexone:

  1. The side-effects from the drug can be quite aggressive
  2. Naltrexone is deadly to the liver and this needs to be constantly monitored
  3. If you miss a dose it can trigger extreme relapse
  4. You need the willpower to take the tablet.

Folks I chat with who use the Sinclair Method frequently state how they battled with the more conventional approaches; I can understand that. I tried Naltrexone and other drugs and it just wasn’t for me. The side effects were too horrible to endure, I will come onto that in a moment.

I was fortunate that I managed to quit with my own unique approach.

I believe Bill Wilson might have accepted Sinclair’s work. It goes without saying, he himself messed around with niacin as well as LSD in an attempt to enhance rehabilitation from alcohol addiction.

AA does not endorse the method

In section 3 of the AA Big Book, it discounts doctors ever being able to use such an approach to cure alcoholism.

I believe if this option had been found in Wilson’s lifetime he might have perhaps backed it. Sadly, AA does not appear to support any of the new options that have been established since Bill died. This is unfortunate, as it is the best institution to get the message out to the most number of full-blown alcoholics.

effect of alcohol on dna

More research required

Actually, I believe it will take some time for this option to acquire broader approval, particularly in the United States. Where the therapy market appears controlled by the ineffective Twelve-step theory.

The Sinclair Method is becoming prominent in other nations and is now offered on the NHS in the United Kingdom. In addition to being used substantially in Scandinavian regions like Sweden, with interesting results.

It is getting recognition in third world countries that do not have a pre-existing Twelve-step rehabilitation therapy market.

It is a more affordable remedy compared with inpatient rehabilitation. Of course, this will be appealing to nations without the facilities to sustain a hospital stay for lots of people.

Why I don’t recommend the method

I don’t recommend AA, purely and simply because I tried it and it didn’t work for me. I do not recommend or endorse Sinclair’s alcohol addiction approach for the exact same reason.

People get very upset when you criticize the approach that worked for them, and I understand why. Beating alcohol addiction is such a monumental and significant process – we can’t help but get very passionate about it.

The method we used in all likelihood saved our lives.

4 stages of alcoholism and recovery

Why it didn’t work for me

There are many reasons why I believe the concept of taking a drug to cure a drug problem is fundamentally flawed:

  1. You have to ‘remember’ to take the tablet – I slowly started relaxing when I would take it and when I would treat myself
  2. Taking a tablet does not deal with the underlying reason why you are drinking
  3. Drugs do not change the subconscious beliefs you have around alcohol – it will always remain a magical, mystical liquid that you are not allowed anymore.
  4. All prescription medication comes with side effects and harm to the body. For me, the side effects of Naltrexone were significantly worse than the most awful hangover I ever had. It’s hard to take a pill that makes you feel that bad and then steals the pleasure of drinking.

The drug-free alternative

stop drinking courseAA is not for everybody and the Sinclair Method is not for everybody either. The same holds true of my own approach. However, I have seen thousands of problem drinkers get back in control of their lives quickly, easily and without having to take a dangerous prescription drug in the process.

If you want more information on my approach, click here.

For more information on my international Quit Drinking Bootcamp’s click here.

And to book your place on my next FREE quit drinking webinar, click here.


Craig Beck - The Stop Drinking Expert

About the author: Stop Drinking Expert - Craig Beck ABNLP. ABHYP. DhP. is an internationally renowned, specialist alcohol cessation coach and quit drinking mentor. Using his experience as a former problem drinker, combined with professionals qualifications, accreditations and practice as an addiction therapist, ICF licensed coach, master practitioner of NLP and master hypnotherapist. Independently respected and rated. Not a substitute for professional medical advice.

Craig Beck

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  1. Here’s a little info from the trenches to supplement your list (I’ve been involved in supporting people on TSM since 2016):

    1. About 80% are able to comply with taking the pill an hour before they drink. There are often (but not always) temporary side effects that fade within a couple of weeks. Only about 5% won’t take the pill because the side effects are too harsh for them.

    2. About 1/3rd of people with Alcohol Use Disorder actually have an underlying psychiatric condition, the remainder might have a little clean up to do after they become indifferent to alcohol via TSM, but that’s easier to handle when you aren’t getting plastered anyway. Most seem to get rid of the compulsion to drink and then go on their merry way.

    3. “Drugs do not change the subconscious beliefs you have around alcohol – it will always remain a magical, mystical liquid that you are not allowed anymore.”

    TSM does just that. It eventually makes you indifferent to alcohol and neutralizes the “magical, mystical feelings. No more boozy “Holy Grail”. These are feelings that reside in the Reward System, which is the home of various addictions. It’s an unconscious part of the brain and knows how to compel you to drink. TSM efficiently erases the fond feelings one may have about alcohol and the irrational love of alcohol itself by reversing the process that put it in your Reward System in the first place.

    4. Most people get along with Naltrexone just fine, after the initial side effects fade (within about 2 weeks). The starting dose can be decreased to help with this. NB, some people don’t get side effects from Naltrexone at all. Sorry the side effects were too harsh for you, that does indeed happen.

    In any case, thanks for the great article and I hope you’re doing well with your current efforts!

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